Onco Wiki / Drogue

Phenoxybenzamine

Vue déterministe de l'entité source de la LJAM. L'autorité clinique demeure avec les ID de la source cités et l'état d'approbation de l ́examinateur.

IDDRUG-PHENOXYBENZAMINE
TypeMédicament
Alias
Dibenzylineblocant alpha irréversible non sélectifФеноксибензамін
Étatreviewed 2026-07-11 | pending_clinical_signoff
MaladiesDIS-PHEOCHROMOCYTOMA
SourcesSRC-ENDOCRINE-SOCIETY-PPGL-2014 SRC-NCCN-NET-2025

Faits sur les drogues

CatégorieAntagoniste des récepteurs adrénergiques non sélectif et irréversible de l'alpha-1/alpha-2
MécanismeCovalently and irreversibly binds alpha-1 and alpha-2 adrenergic receptors, producing a long-acting, non-competitive blockade of catecholamine-mediated vasoconstriction. In pheochromocytoma / paraganglioma (PPGL), preoperative alpha-blockade with phenoxybenzamine (or a selective alpha-1 blocker such as doxazosin) is mandatory before surgery to prevent an intraoperative hypertensive crisis from catecholamine release during tumor manipulation (Endocrine Society 2014 PPGL guideline). Alpha-2 blockade component can cause reflex tachycardia and orthostatic hypotension, which is more pronounced than with selective alpha-1 agents.
Dose typiqueStarting dose typically 10 mg PO BID, titrated upward in 10-20 mg/day increments every few days to achieve blood-pressure normalization and resolution of orthostatic/paroxysmal symptoms, per Endocrine Society 2014 PPGL guideline (SRC-ENDOCRINE-SOCIETY-PPGL-2014); usual preoperative course runs roughly one to two weeks before surgery to allow adequate, sustained alpha-blockade and intravascular volume re-expansion. Exact target BP/HR thresholds and final maintenance dose are individualized by the treating team and are NOT fixed numeric values in this stub -- see RF-PHEO-INADEQUATE-ALPHA-BLOCKADE for the hard sequencing gate this drug exists to satisfy.
Ukraine enregistréeFaux
NSZU rembourséFaux
Ukraine vérifiée pour la dernière fois2026-07-11

Notes

Historically the guideline-preferred agent for preoperative PPGL alpha-blockade because its irreversible, long-acting blockade is harder to overcome with catecholamine surge during tumor handling; doxazosin (selective, reversible alpha-1 blocker; see DRUG-DOXAZOSIN) is a widely used, more available and better-tolerated alternative with less reflex tachycardia -- choice between the two is per local practice/availability, not modelled as a KB-level preference. STUB pending clinical co-lead signoff (CHARTER §6.1, dev-mode-exempted).

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