Onco Wiki / Drogue

Cabergoline

Vue déterministe de l'entité source de la LJAM. L'autorité clinique demeure avec les ID de la source cités et l'état d'approbation de l ́examinateur.

IDDRUG-CABERGOLINE
TypeMédicament
Alias
DostinexКаберголін
Étatreviewed 2026-07-11 | pending_clinical_signoff
MaladiesDIS-PITUITARY-ADENOMA
SourcesSRC-NCCN-CNS-2025

Faits sur les drogues

CatégorieAgoniste du récepteur de dopamine D2 dérivé de l'ergot
MécanismeSelective, high-affinity D2-dopamine receptor agonist with a long elimination half-life (~65 hours) permitting once- or twice-weekly oral dosing. Activates D2 receptors on pituitary lactotroph cells, suppressing prolactin synthesis/secretion and inducing lactotroph adenoma shrinkage in the majority of prolactinomas. First-line therapy for prolactinoma; superior prolactin-normalization rate, tumor-shrinkage rate, and tolerability compared with bromocriptine (older, less selective dopamine agonist).
Dose typiqueStart 0.25 mg PO twice weekly (or 0.5 mg PO once weekly); titrate by 0.25-0.5 mg/week increments no more often than every 4 weeks according to serum prolactin response, to a typical maintenance dose of 0.5-2 mg/week in divided doses twice weekly (occasionally higher, up to ~4.5 mg/week, in macroprolactinoma resistant to lower doses). Take with food to reduce nausea. Confirm exact titration schedule with treating endocrinology team.
Ukraine enregistréeVrai
NSZU rembourséFaux
Ukraine vérifiée pour la dernière fois2026-07-11

Notes

STUB pending clinical co-lead signoff (CHARTER §6.1 — dev-mode-exempted, safe to merge as draft content, not published/verified clinical advice). Cabergoline is first-line therapy for prolactinoma per the Disease narrative (preferred over bromocriptine for prolactin-normalization rate, tumor shrinkage, and tolerability). Bromocriptine itself is not yet authored as a separate Drug entity in this KB — deferred as an open gap (see DIS-PITUITARY-ADENOMA proposal notes) since the narrative names it only as a comparator, not as a distinct recommended pathway.

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Protocole thérapeutique