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Gastrámica / GEJ adenocarcinoma · línea 1 · FLOT

Vista determinista de la entidad fuente YAML. La autoridad clínica sigue con los ID de fuente citados y estado de firma del revisor.

Registro de base de conocimiento para la auditoría. Contenido clínico provisional: esto no es una prescripción. Un oncólogo debe verificar fuentes originales, aplicabilidad y estado de revisión.

Fuente YAML: registro completo

Línea de tratamiento1
Trackagresivo
Régimen vinculadoREG-FLOT
IDIND-GASTRIC-OLIGOMET-SYSTEMIC-PLUS-LOCAL
TipoIndicación
Situaciónreviewed 2026-05-08 | pending_clinical_signoff | actionability review required
EnfermedadesDIS-GASTRIC
FuentesSRC-ESMO-GASTRIC-2024 SRC-NCCN-GASTRIC-2025 SRC-OMEC-1-KROESE-2023 SRC-RENAISSANCE-AIO-FLOT5

Notas

Gastric oligometastatic systemic-plus-local track per OMEC-1 consensus + RENAISSANCE / AIO-FLOT5 design. Confidence: moderate (consensus + ongoing-trial design; NCCN 2B). RENAISSANCE primary OS publication pending — re-grade to 2A and evidence_level high once full results published (D2 follow-up). §17 phases: NOT populated for v0.1 (planning doc gi2_wave §4.5 recommendation 2). Local-therapy entities (metastasectomy Surgery, SBRT RadiationCourse) for gastric oligomet are future Phase C extensions. Sequence (induction FLOT → restaging → local therapy → adjuvant FLOT) described in description / rationale / do_not_do text only. recommended_regimen: REG-FLOT (backfilled 2026-05-08 after C1 PR #435 created REG-FLOT; closes #438). Algorithm wiring deferred — ALGO-GASTRIC-METASTATIC-1L does not yet have an oligomet branch. D2 follow-up: extend algorithm with oligomet decision step gated by RF-OLIGOMET-DEFINITION. Engine smoke (synthetic patient: gastric, mets=liver_2_lesions + 1_lymph_node, ECOG 1, primary_controllable=true, HER2 negative): RF-OLIGOMET-DEFINITION fires; no algorithm branch consumes it yet. Indication is reachable via direct ID lookup but not via current decision-tree rou...

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