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Vulvar und vaginales Plattenepithelkarzinom

Deterministische Ansicht der Quelle YAML Entität. Klinische Autorität bleibt mit den zitierten Quell-IDs und Rezensenten Sign-off Zustand.

IDDIS-VULVAR-VAGINAL-SCC
ArtErkrankung
Aliase
HPV-assoziierte Vulvar-SCCLichen-Sklerosus-abgeleitete SCCVIN-abgeleitete SCCVaginal SCCVulvar SCCПлоскоклітинна карцинома вульви та піхви
Statusreviewed 2026-05-18 | pending_clinical_signoff
ErkrankungenNone declared
QuellenSRC-IARC-MONO-100B-2012 SRC-NCCN-CERVICAL-2025

Informational support. All recommendations must be verified by a qualified oncologist. Engineering checks are not clinical validation or treatment approval.

Quelle: YAML

icd_o_3_morphology8070/3
icd_o_3_topography["C51", "C52"]
icd_10C51, C52
who_classificationWHO Weibliche Genitaltumore 5 ed (2020): Vulvar SCC (HPV-assoziiert + HPV-unabhängig) und Vaginal SCC

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Anmerkungen

Two biological subgroups managed similarly anatomically but with distinct prevention implications: HPV-driven (vaccination prevents precursor lesions; screening with vulvar exam + biopsy of any persistent lesion) vs HPV-independent (lichen sclerosus surveillance is the dominant prevention modality; topical clobetasol may reduce malignant transformation in select cohorts). Treatment: early-stage — wide local excision ± inguinal sentinel node biopsy (GROINSS-V paradigm replacing routine complete inguinofemoral lymphadenectomy); locally advanced — definitive chemoradiation (cisplatin + RT); metastatic — pembrolizumab if PD-L1+ (KEYNOTE-158 cohort). Vaginal SCC managed similarly with RT-based approaches (anatomic constraints limit surgical options).

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