BCL6-Umstellung (3q27) durch FISH-Bremsen

Deterministische Ansicht der Quelle YAML Entität. Klinische Autorität bleibt mit den zitierten Quell-IDs und Rezensenten Sign-off Zustand.

ID	`BIO-BCL6-REARRANGEMENT`
Art	Biomarker
Aliase	BCL6 NeuordnungBCL6-Umstellung (3q27) — FISH-Ausbruch
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Erkrankungen	`DIS-HGBL-DH`
Quellen	`SRC-NCCN-BCELL-2025`

Biomarker-Fakten

Biomarker-Typ	gene_fusion
Angaben zur Mutation	{"functional_impact": "constitutive BCL6 over-expression — blocks differentiation, drives germinal-center program", "gene": "BCL6", "variant_type": "fusion (multiple partners; promoter substitution → over-expression)"}
Messung	VerfahrenFISH-Bruchsonde zur FFPE-Biopsie Einheitencategorical (positive \| negative)
Verwandte Biomarker	`BIO-DOUBLE-HIT` `BIO-MYC-REARRANGEMENT` `BIO-BCL2-REARRANGEMENT`

Anmerkungen

Cross-disease relevance: - **HGBL-DH/THL**: BCL6 rearrangement is the third member of double-/ triple-hit definition. MYC + BCL6 = double-hit (less common than MYC + BCL2). MYC + BCL2 + BCL6 = triple-hit (rarest, worst prognosis). Drives DA-EPOCH-R over R-CHOP. - **DLBCL**: ~20-30% have isolated BCL6 rearrangement — does NOT drive treatment alone (only when combined with MYC). - **FL**: rare ~10%. Required FISH on every newly-diagnosed DLBCL alongside MYC + BCL2 to identify HGBL-DH/THL early.

Verwendet von

Biomarker

BIO-BCL6-IHC - BCL6 IHC (Proteinexpression)
BIO-DOUBLE-HIT - Doppelhit (MYC + BCL2 und/oder BCL6-Neuordnungen)

Anwendungsgebiet

IND-HGBL-DH-1L-DAEPOCHR - IND-HGBL-DH-1L-DAEPOCHR
IND-HGBL-DH-1L-RCHOP - IND-HGBL-DH-1L-RCHOP

Fragebogen

QUEST-HGBL-DH-1L-STUB - Hochgradiges B-Zell-Lymphom, Doppel-Hit / Dreifach-Hit — erste Zeile