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BCL6 IHC (Proteinexpression)

Deterministische Ansicht der Quelle YAML Entität. Klinische Autorität bleibt mit den zitierten Quell-IDs und Rezensenten Sign-off Zustand.

IDBIO-BCL6-IHC
ArtBiomarker
Aliase
B-Zell-Lymphom 6 ProteinBCL-6 IHCBCL6 ImmunhistochemieBCL6 Protein
Statusreviewed 2026-05-05 | pending_clinical_signoff
ErkrankungenNone declared
QuellenSRC-NCCN-BCELL-2025

Biomarker-Fakten

Biomarker-Typprotein_expression_ihc
Angaben zur Mutation{"gene_id_ncbi": 604, "gene_symbol": "BCL6", "note": "BCL6 is a transcriptional repressor essential for germinal center (GC) B-cell development. BCL6 IHC detects nuclear protein expression (not rearrangement). Positive = nuclear staining. Threshold: >30% nuclear positivity typically used as cut-off for GC-origin classification (Hans algorithm). Note: BIO-BCL6-REARRANGEMENT is a distinct biomarker (chromosomal translocation detected by FISH) — different from BCL6 protein expression by IHC.\n"}
Messung
VerfahrenIHC auf FFPE-Biopsie. Anti-BCL6 Antikörper (Clone PG-B6p). Kernbefleckung erzielte als % positive Tumorzellen. Hans-Algorithmus-Schwelle: > 30% Nuklei positiv = BCL6+. Automatisierte Bewertung auf digitalen Pathologie-Plattformen zunehmend verwendet.
Verwandte BiomarkerBIO-CD10-IHC BIO-MUM1-IHC BIO-DLBCL-COO-HANS BIO-BCL6-REARRANGEMENT BIO-MYC-REARRANGEMENT

Anmerkungen

BCL6 IHC is a core component of the Hans algorithm for DLBCL cell-of-origin classification. While gene expression profiling (GEP, Lymph2Cx assay) is the reference standard for GCB/ABC classification, Hans IHC is widely used in resource-limited settings (concordance with GEP ~80%). BCL6 protein expression is distinct from BCL6 chromosomal rearrangement (t(3;v) translocations detected by FISH) — both exist independently. BCL6 rearrangement occurs in ~25-35% of DLBCL and may be present in either GCB or non-GCB subtypes.

Verwendet von

Biomarker