OpenOnco · Treatment Plan

Treatment plan — DIS-PMF

PLAN-BMA-JAK2_V617F_PMF-V1 · v1 · 2026-05-04

Patient

BMA-JAK2_V617F_PMF · Algorithm: ALGO-PMF-1L

Clinical significance of mutations (ESCAT)

Tumor-board context — the engine does not use these tiers to rank tracks

✅ Covered biomarkers (matched in KB)

Biomarker	Variant	ESCAT	Evidence	Clinical significance	Drugs	Sources
No clinically actionable variants matched in this profile.

⚠️ Not included in plan

Biomarker	Status
BIO-JAK2	Not in KB — ask clinician to verify

Treatment options (2 tracks)

Standard plan

★ DEFAULT

Indication

IND-PMF-1L-OBSERVATION

Regimen

Ruxolitinib (PMF — symptomatic splenomegaly / constitutional symptoms)

Drugs + NSZU

Ruxolitinib (DRUG-RUXOLITINIB) Start by baseline platelet count: plt 50-100K → 5 mg BID; 100-200K → 15 mg BID; >200K → 20 mg BID. Titrate by toxicity (max 25 mg BID). · continuous PO twice daily; NEVER abrupt-stop (taper) · PO ✓ NSZU covered

Supportive care

SUP-HBV-PROPHYLAXIS, SUP-HSV-PROPHYLAXIS

Reason

Engine default per algorithm ALGO-PMF-1L: {'step': 4, 'outcome': False, 'branch': {'result': 'IND-PMF-1L-OBSERVATION'}, 'fired_red_flags': [], 'winner_red_flag': None}

Aggressive plan

Indication

IND-PMF-1L-RUXOLITINIB

Regimen

Ruxolitinib (PMF — symptomatic splenomegaly / constitutional symptoms)

Drugs + NSZU

Ruxolitinib (DRUG-RUXOLITINIB) Start by baseline platelet count: plt 50-100K → 5 mg BID; 100-200K → 15 mg BID; >200K → 20 mg BID. Titrate by toxicity (max 25 mg BID). · continuous PO twice daily; NEVER abrupt-stop (taper) · PO ✓ NSZU covered

Supportive care

SUP-HBV-PROPHYLAXIS, SUP-HSV-PROPHYLAXIS

Reason

Alternative track presented for HCP consideration

Pre-treatment investigations

Investigations before treatment start · critical / standard / desired · merged across tracks

ID	Name	Priority	Category	Where to order	Needed for
TEST-BCR-ABL-JAK2	BCR-ABL + JAK2 + CALR + MPL	Critical	genomic	CSD Lab ✓ (code TBC)	all tracks
TEST-BM-ASPIRATE	Bone Marrow Aspirate	Critical	histology	—	all tracks
TEST-BM-TREPHINE	Bone Marrow Trephine	Critical	histology	—	all tracks
TEST-CBC	Complete Blood Count with Differential	Critical	lab	—	all tracks
TEST-CMP	Comprehensive Metabolic Panel	Critical	lab	—	all tracks
TEST-COAG-PANEL	Coagulation Panel	Critical	lab	—	all tracks
TEST-FISH-PANEL	FISH (Fluorescence In Situ Hybridization)	Critical	genomic	CSD Lab ✓ (code TBC)	all tracks
TEST-FLOW-CYTOMETRY	Flow Cytometry	Critical	histology	CSD Lab ✓ (code TBC)	all tracks
TEST-HBV-SEROLOGY	Hepatitis B Serology Panel (HBsAg, anti-HBc total, anti-HBs)	Critical	lab	—	all tracks
TEST-HCV-ANTIBODY	HCV Antibody	Critical	lab	—	all tracks
TEST-HIV-SEROLOGY	HIV Antibody/Antigen	Critical	lab	—	all tracks
TEST-KARYOTYPE	Karyotype	Critical	genomic	CSD Lab ✓ (code TBC)	all tracks
TEST-LDH	Lactate Dehydrogenase	Critical	lab	—	all tracks
TEST-LFT	Liver Function Tests (ALT, AST, bilirubin, ALP, GGT, albumin)	Critical	lab	—	all tracks
TEST-NGS-MYELOID-PANEL	Myeloid NGS Panel	Critical	genomic	CSD Lab ✓ (code TBC)	all tracks
TEST-PERIPHERAL-SMEAR	Peripheral Blood Smear	Critical	lab	CSD Lab ✓ (code TBC)	all tracks
TEST-CMV-SEROLOGY	CMV IgG/IgM	Standard	lab	—	aggressive
TEST-IRON-PANEL	Iron Panel	Standard	lab	—	all tracks
TEST-RETICULOCYTE	Reticulocyte Count	Standard	lab	—	all tracks
TEST-D-DIMER	D-Dimer	Desired	lab	—	standard

Red flags — PRO / CONTRA aggressive

PRO-AGGRESSIVE

Triggers that push toward the aggressive track

Primary myelofibrosis with DIPSS-Plus intermediate-2 or high risk — alloHCT referral mandatory in eligible patients (only curative option); ruxolitinib for symptom + spleen control while awaiting transplantRF-DIPSS-PLUS-HIGH
PMF with anemia as dominant clinical problem (Hb <10 g/dL OR transfusion-dependent) — momelotinib preferred over ruxolitinib (MOMENTUM trial: spleen + symptom + Hb improvement)RF-PMF-ANEMIA-DOMINANT
PMF progressing toward AML (blasts in PB ≥10% accelerated, ≥20% blast-phase / post-MPN AML), rapid splenic enlargement, or rising LDH — re-stage with BM, accelerate alloHCT, consider AML-style therapy if blast-phaseRF-PMF-BLAST-PROGRESSION
PMF patient elderly or frail (age ≥75, ECOG ≥3, or HCT-CI ≥4) — alloHCT off the table; symptom-directed therapy (ruxolitinib for splenomegaly + symptoms, momelotinib for anemia, transfusion + supportive care)RF-PMF-FRAILTY-AGE
PMF intermediate-2 or high risk by DIPSS-Plus — alloHCT referral mandatory in eligible patients (only curative option); ruxolitinib for symptomatic splenomegaly + symptoms while awaiting transplantRF-PMF-HIGH-RISK-DIPSS

CONTRA-AGGRESSIVE

Hard contraindications to escalation

What NOT to do

Explicit prohibitive rules, each grounded in a regimen / supportive care / contraindication entity

Standard plan (IND-PMF-1L-OBSERVATION)

Do not skip DIPSS-Plus / MIPSS70 risk-stratification at presentation — critical for long-term planning.
Do not prescribe ruxolitinib to asymptomatic patients — change in natural history not proven; toxicity + cost are unnecessary.
Do not skip pre-JAKi HBV / TB screening + active prophylaxis.
Do not abrupt-stop ruxolitinib — taper over 1-2 weeks.
Do not skip alloHCT discussion for intermediate-2 / high — switch to aggressive-track indication via RF.

Aggressive plan (IND-PMF-1L-RUXOLITINIB)

Do not abrupt-stop ruxolitinib — taper over 1-2 weeks; cytokine rebound may be life-threatening.
Do not skip pre-JAKi HBV / TB / HSV screening + active prophylaxis.
Do not skip alloHCT discussion for transplant-eligible — JAKi does not cure MF.
Do not use full ruxolitinib dose at plt 50-100K — start at 5 mg BID + titrate.
Do not combine with strong CYP3A4 inhibitor without dose reduction (50%).

MDT brief

Skills (recommended) — for consideration (1)

Clinical pharmacist recommended
Chemoimmunotherapy regimen — drug-drug interactions, dose adjustments, premedication.
skill: clinical_pharmacistv0.1.0reviewed 2026-04-25STUBsign-offs: 0lead: TBD

Open questions (1, 0 blocking)

OQ-LDH-CURRENT
What is the current LDH? Marker of tumor burden and transformation.
LDH is part of the prognostic indices of indolent lymphomas.
→ hematologist

Data quality

Unevaluated RedFlags: RF-DIPSS-PLUS-HIGH, RF-PMF-ANEMIA-DOMINANT, RF-PMF-BLAST-PROGRESSION, RF-PMF-FRAILTY-AGE, RF-PMF-HIGH-RISK-DIPSS, RF-PMF-INFECTION-SCREENING, RF-PMF-ORGAN-DYSFUNCTION

Skill catalog (1/16 activated in this plan)

All registered virtual specialists. ✓ — activated for this case; ○ — not activated (available for other clinical scenarios).

Specialist	skill_id	Version	Last reviewed	Domain
Cellular therapy specialist (CAR-T)	`cellular_therapy_specialist`	v0.1.0	2026-04-25	cellular_therapy
Clinical pharmacist	`clinical_pharmacist`	v0.1.0	2026-04-25	clinical_pharmacy
Hematologist / oncohematologist	`hematologist`	v0.1.0	2026-04-25	hematology_oncology
Hematopathologist (lymphoma / leukemia / myeloma)	`hematopathologist`	v0.1.0	2026-04-25	hematopathology
Infectious disease / hepatology	`infectious_disease_hepatology`	v0.1.0	2026-04-25	infectious_diseases
Medical oncologist (solid-tumor chemotherapist)	`medical_oncologist`	v0.1.0	2026-04-25	solid_oncology
Molecular geneticist / molecular oncologist	`molecular_geneticist`	v0.1.0	2026-04-25	molecular_oncology
Palliative care	`palliative_care`	v0.1.0	2026-04-25	palliative_care
Pathologist (general)	`pathologist`	v0.1.0	2026-04-25	pathology
Primary care / family physician	`primary_care`	v0.1.0	2026-04-25	primary_care
Psycho-oncologist	`psychologist`	v0.1.0	2026-04-25	psychosocial
Radiation oncologist	`radiation_oncologist`	v0.1.0	2026-04-25	radiation_oncology
Radiologist	`radiologist`	v0.1.0	2026-04-25	diagnostic_imaging
Social worker / case manager	`social_worker_case_manager`	v0.1.0	2026-04-25	psychosocial
Surgical oncologist	`surgical_oncologist`	v0.1.0	2026-04-25	surgical_oncology
Transplant specialist (BMT)	`transplant_specialist`	v0.1.0	2026-04-25	cellular_therapy

Sources cited

SRC-COMFORT-I-VERSTOVSEK-2012: A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis (2012)
SRC-DIPSS-PLUS-GANGAT-2011: DIPSS plus: a refined Dynamic International Prognostic Scoring System for primary myelofibrosis that incorporates prognostic information from karyotype, platelet count, and transfusion status (2011)
SRC-ESMO-MPN-2015: Philadelphia-negative chronic myeloproliferative neoplasms: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (2015)
SRC-NCCN-MPN-2025: NCCN Clinical Practice Guidelines in Oncology: Myeloproliferative Neoplasms (v.X.2025)

Experimental options (clinical trials)

Third plan track — open-enrollment trials from ClinicalTrials.gov. Render-time metadata; engine selection is not affected by this block (CHARTER §8.3). Last synced: 2026-05-04.

NCT	Title	Phase	Status	Sponsor	UA
NCT07317700	A Clinical Trial of Flonoltinib Maleate for Intermediate or High-Risk Myelofibrosis	PHASE3	RECRUITING	Chengdu Zenitar Biomedical Technology Co., Ltd	—
NCT05280509	Study of TL-895 Combined With Ruxolitinib in JAKi Treatment-Naïve MF Subjects and Subjects With MF Who Have a Suboptimal Response to Ruxolitinib	PHASE1 / PHASE2	RECRUITING	Telios Pharma, Inc.	—
NCT06770842	Ropeginterferon Alfa 2b Plus Ruxolitinib for Myelofibrosis	PHASE2	RECRUITING	The University of Hong Kong	—
NCT05123365	An Optimal Dose Finding Study of N-Acetylcysteine in Patients With Myeloproliferative Neoplasms	PHASE1 / PHASE2	RECRUITING	University of California, Irvine	—
NCT06218628	Pacritinib w/ Talazoparib in Pts w/ Myeloproliferative Neoplasms Unresponsive to JAK2 Inhibition	PHASE1	RECRUITING	Fox Chase Cancer Center	—
NCT07104799	Momelotinib During and After HCT in Myelofibrosis	PHASE1	RECRUITING	Massachusetts General Hospital	—
NCT07020533	A Vaccine (CMV-MVA Triplex Vaccine) for the Enhancement of CMV-Specific Immunity and the Prevention of CMV Viremia in Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplant	PHASE1	RECRUITING	City of Hope Medical Center	—
NCT07362225	MPN PROGRESSion Registry: Observational Study Tracking Symptoms, Treatments, and Disease Progression in People With Myeloproliferative Neoplasms (MPNs)	N/A	RECRUITING	MPN Research Foundation	—
NCT02897297	Myeloproliferative Neoplastic Diseases Observatory From Brest	N/A	RECRUITING	University Hospital, Brest	—
NCT01973881	Quantitative MRI for Myelofibrosis	N/A	RECRUITING	University of Michigan Rogel Cancer Center	—

Verify recruitment status directly with the trial site. ctgov data can lag behind current UA-site status.

Option availability in Ukraine

Per-track UA registration · NSZU · cost · access pathway. Render-time metadata; engine selection does not depend on these fields (CHARTER §8.3).

Option	UA registration	NSZU	Cost orientation	Access pathway
Standard plan Ruxolitinib (PMF — symptomatic splenomegaly / constitutional symptoms) (REG-RUX-PMF)	✓ registered	✓ covered	₴-? — verify pathway	NSZU formulary
Aggressive plan Ruxolitinib (PMF — symptomatic splenomegaly / constitutional symptoms) (REG-RUX-PMF)	✓ registered	✓ covered	₴-? — verify pathway	NSZU formulary
Trial · NCT07317700 A Clinical Trial of Flonoltinib Maleate for Intermediate or High-Risk Myelofibrosis No UA site listed — international referral required	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor
Trial · NCT05280509 Study of TL-895 Combined With Ruxolitinib in JAKi Treatment-Naïve MF Subjects and Subjects With MF Who Have a Suboptimal Response to Ruxolitinib No UA site listed — international referral required	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor
Trial · NCT06770842 Ropeginterferon Alfa 2b Plus Ruxolitinib for Myelofibrosis No UA site listed — international referral required	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor
Trial · NCT05123365 An Optimal Dose Finding Study of N-Acetylcysteine in Patients With Myeloproliferative Neoplasms No UA site listed — international referral required	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor
Trial · NCT06218628 Pacritinib w/ Talazoparib in Pts w/ Myeloproliferative Neoplasms Unresponsive to JAK2 Inhibition No UA site listed — international referral required	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor
Trial · NCT07104799 Momelotinib During and After HCT in Myelofibrosis No UA site listed — international referral required	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor
Trial · NCT07020533 A Vaccine (CMV-MVA Triplex Vaccine) for the Enhancement of CMV-Specific Immunity and the Prevention of CMV Viremia in Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplant No UA site listed — international referral required	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor
Trial · NCT07362225 MPN PROGRESSion Registry: Observational Study Tracking Symptoms, Treatments, and Disease Progression in People With Myeloproliferative Neoplasms (MPNs) No UA site listed — international referral required	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor
Trial · NCT02897297 Myeloproliferative Neoplastic Diseases Observatory From Brest No UA site listed — international referral required	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor
Trial · NCT01973881 Quantitative MRI for Myelofibrosis No UA site listed — international referral required	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor

Cost information is orientation. Verify with a specific pharmacy / foundation / trial site. Status updated: 2026-05-04.

plan_id: PLAN-BMA-JAK2_V617F_PMF-V1 | version: 1 | generated: 2026-05-04T14:13:16.628790+00:00

Per FDA non-device CDS positioning (CHARTER §15): Outpatient oncology treatment planning to support tumor-board discussion. Not a medical device; not for autonomous clinical decision-making.

Per FDA non-device CDS positioning (CHARTER §15): Both treatment options below are presented for review. The engine's selection of a 'recommended' default does not constitute a clinical decision. Final treatment selection requires HCP judgment incorporating information not available to the system.

This document is an informational resource supporting tumor-board discussion (per CHARTER §11). It is not a system that makes clinical decisions. Every recommendation must be verified by the treating physician.