BCL6 IHC (protein expression)

Детермінований перегляд YAML-сутності з джерельної бази. Клінічний авторитет лишається за вказаними source ID та статусом клінічного sign-off.

ID	`BIO-BCL6-IHC`
Тип	Біомаркер
Синоніми	B-cell lymphoma 6 proteinBCL-6 IHCBCL6 immunohistochemistryBCL6 protein
Статус	переглянуто 2026-05-05 \| очікує клінічного підпису
Хвороби	Не вказано
Джерела	`SRC-NCCN-B-CELL-2025`

Дані про біомаркер

Тип біомаркера	protein_expression_ihc
Деталі мутації	{"gene_id_ncbi": 604, "gene_symbol": "BCL6", "note": "BCL6 is a transcriptional repressor essential for germinal center (GC) B-cell development. BCL6 IHC detects nuclear protein expression (not rearrangement). Positive = nuclear staining. Threshold: >30% nuclear positivity typically used as cut-off for GC-origin classification (Hans algorithm). Note: BIO-BCL6-REARRANGEMENT is a distinct biomarker (chromosomal translocation detected by FISH) — different from BCL6 protein expression by IHC.\n"}
Вимірювання	MethodIHC on FFPE biopsy. Anti-BCL6 antibody (clone PG-B6p). Nuclear staining scored as % positive tumor cells. Hans algorithm threshold: >30% nuclei positive = BCL6+. Automated scoring on digital pathology platforms increasingly used.
Пов’язані біомаркери	`BIO-CD10-IHC` `BIO-MUM1-IHC` `BIO-DLBCL-COO-HANS` `BIO-BCL6-REARRANGEMENT` `BIO-MYC-REARRANGEMENT`

Нотатки

BCL6 IHC is a core component of the Hans algorithm for DLBCL cell-of-origin classification. While gene expression profiling (GEP, Lymph2Cx assay) is the reference standard for GCB/ABC classification, Hans IHC is widely used in resource-limited settings (concordance with GEP ~80%). BCL6 protein expression is distinct from BCL6 chromosomal rearrangement (t(3;v) translocations detected by FISH) — both exist independently. BCL6 rearrangement occurs in ~25-35% of DLBCL and may be present in either GCB or non-GCB subtypes.

Де використовується

Біомаркер

BIO-CD10-IHC - CD10 IHC (CALLA, neprilysin)
BIO-MUM1-IHC - MUM1/IRF4 IHC (Multiple Myeloma oncogene 1)