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APL patient with positive HBV / HCV / HIV serology, latent TB, or active uncontrolled inf...

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IDRF-APL-INFECTION-SCREENING
TipoSinal de alerta
Estadoreviewed 2026-04-25 | pending_clinical_signoff
DoençasDIS-APL
FontesSRC-ELN-APL-2019 SRC-NCCN-AML-2025

Origem da bandeira vermelha

DefiniçãoAPL patient with positive HBV / HCV / HIV serology, latent TB, or active uncontrolled infection — needs antiviral prophylaxis before initiating consolidation; ATRA initiation should NOT wait for these results
Direcção clínicaaguentar
Categoriarastreamento de infecções

Lógica de Desencadeamento

{
  "any_of": [
    {
      "finding": "hbsag",
      "value": "positive"
    },
    {
      "finding": "anti_hbc_total",
      "value": "positive"
    },
    {
      "finding": "hcv_rna",
      "value": "positive"
    },
    {
      "finding": "hiv_status",
      "value": "positive"
    },
    {
      "finding": "active_uncontrolled_infection",
      "value": true
    }
  ],
  "type": "composite"
}

Notas

Direction "hold" — surfaces a pre-consolidation prerequisite. APL induction (ATRA + ATO ± idarubicin) does not delay for serology; consolidation cycles use anthracycline-containing regimens that warrant HBV-active prophylaxis if serologically at risk. STUB — requires clinical co-lead signoff.

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