Doxazosin
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| ID | DRUG-DOXAZOSIN |
|---|---|
| Tipo | Fármaco |
| Alegais | Cardurabloqueador seletivo alfa-1Доксазозин |
| Estado | reviewed 2026-07-11 | pending_clinical_signoff |
| Doenças | DIS-PHEOCHROMOCYTOMA |
| Fontes | SRC-ENDOCRINE-SOCIETY-PPGL-2014 SRC-NCCN-NET-2025 |
Fatos sobre as drogas
| Classe | Antagã seletivo dos receptores adrenérgicos alfa-1 competitivo |
|---|---|
| Mecanismo | Selectively and reversibly blocks post-synaptic alpha-1 adrenergic receptors, reducing catecholamine-mediated peripheral vasoconstriction with less reflex tachycardia than non-selective irreversible agents (phenoxybenzamine) because alpha-2 presynaptic auto-inhibition of norepinephrine release is preserved. Used as an alternative preoperative alpha-blocker in pheochromocytoma / paraganglioma (PPGL) where mandatory preoperative alpha-blockade is required before surgery to prevent intraoperative hypertensive crisis (Endocrine Society 2014 PPGL guideline). |
| Dose típica | Starting dose typically 1-2 mg PO once daily, titrated upward every few days as tolerated toward blood-pressure normalization and symptom control ahead of PPGL surgery, per Endocrine Society 2014 PPGL guideline (SRC-ENDOCRINE-SOCIETY-PPGL-2014); usual ceiling in general antihypertensive use is 16 mg/day, though the dose actually required for adequate preoperative PPGL blockade is individualized by the treating team. Usual preoperative course runs roughly one to two weeks before surgery. Exact target BP/HR thresholds are NOT fixed numeric values in this stub -- see RF-PHEO-INADEQUATE-ALPHA-BLOCKADE for the hard sequencing gate this drug exists to satisfy. |
| Ucrânia registada | Verdade |
| NSZU reembolsado | Falso |
| Ucrânia verificada pela última vez | 2026-07-11 |
Notas
Selective alpha-1 blockade gives less reflex tachycardia and easier general availability than phenoxybenzamine (DRUG-PHENOXYBENZAMINE), making doxazosin a commonly used practical alternative for mandatory preoperative PPGL alpha-blockade; choice between the two is per local practice/availability, not modelled as a KB-level preference. STUB pending clinical co-lead signoff (CHARTER §6.1, dev-mode-exempted).
Usado por
Fármaco
DRUG-PHENOXYBENZAMINE- Phenoxybenzamine
Esquema terapêutico
REG-ALPHA-BLOCKADE-PREOP-PHEO- bloqueio alfa- adrenérgico pré-operatório (phenoxybenzamine, antes do feocromocitoma/paragão...