Cabergoline
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| ID | DRUG-CABERGOLINE |
|---|---|
| Tipo | Fármaco |
| Alegais | DostinexКаберголін |
| Estado | reviewed 2026-07-11 | pending_clinical_signoff |
| Doenças | DIS-PITUITARY-ADENOMA |
| Fontes | SRC-NCCN-CNS-2025 |
Fatos sobre as drogas
| Classe | Agonista do receptor de dopamina D2 derivado de ergotos |
|---|---|
| Mecanismo | Selective, high-affinity D2-dopamine receptor agonist with a long elimination half-life (~65 hours) permitting once- or twice-weekly oral dosing. Activates D2 receptors on pituitary lactotroph cells, suppressing prolactin synthesis/secretion and inducing lactotroph adenoma shrinkage in the majority of prolactinomas. First-line therapy for prolactinoma; superior prolactin-normalization rate, tumor-shrinkage rate, and tolerability compared with bromocriptine (older, less selective dopamine agonist). |
| Dose típica | Start 0.25 mg PO twice weekly (or 0.5 mg PO once weekly); titrate by 0.25-0.5 mg/week increments no more often than every 4 weeks according to serum prolactin response, to a typical maintenance dose of 0.5-2 mg/week in divided doses twice weekly (occasionally higher, up to ~4.5 mg/week, in macroprolactinoma resistant to lower doses). Take with food to reduce nausea. Confirm exact titration schedule with treating endocrinology team. |
| Ucrânia registada | Verdade |
| NSZU reembolsado | Falso |
| Ucrânia verificada pela última vez | 2026-07-11 |
Notas
STUB pending clinical co-lead signoff (CHARTER §6.1 — dev-mode-exempted, safe to merge as draft content, not published/verified clinical advice). Cabergoline is first-line therapy for prolactinoma per the Disease narrative (preferred over bromocriptine for prolactin-normalization rate, tumor shrinkage, and tolerability). Bromocriptine itself is not yet authored as a separate Drug entity in this KB — deferred as an open gap (see DIS-PITUITARY-ADENOMA proposal notes) since the narrative names it only as a comparator, not as a distinct recommended pathway.
Usado por
Esquema terapêutico
REG-CABERGOLINE-PROLACTINOMA- Cabergoline para prolactinoma (agonista de dopamina, de primeira linha)