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Estado do VIH (4a-Genidade Ag/Ab triagem combinada)

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IDBIO-HIV-STATUS
TipoBiomarcador
Alegais
Anti-HIVSerologia do VIHSituação no VIHVIH-1/2 Ag/AbСтатус ВІЛ (4-е покоління Ag/Ab скринінг)
Estadoreviewed 2026-04-26 | pending_clinical_signoff
DoençasDIS-BURKITT DIS-CHL DIS-DLBCL-NOS DIS-KAPOSI
FontesSRC-ESMO-DLBCL-2024 SRC-NCCN-BCELL-2025

Fatos de biomarcadores

Tipo de biomarcadorviral_serology
Medição
MétodoFourth-generation HIV-1/2 antigen/antibody combo immunoassay (detects p24 antigen + anti-HIV-1/2 antibodies; window period ~10-14 days). Reactive screen → confirmatory HIV-1/2 antibody differentiation assay + HIV-1 RNA viral load if newly diagnosed.
Unidadescategorical: HIV+ (with VL/CD4 if known) | HIV-
Biomarcadores relacionadosBIO-HBV-STATUS BIO-HCV-STATUS BIO-EBV-STATUS

Notas

Mandatory pre-treatment screening for any aggressive lymphoma (Burkitt, DLBCL, plasmablastic, primary effusion) and Hodgkin lymphoma — HIV-associated subtypes have distinct biology, increased CNS-IPI risk, and require coordinated cART before / during cytotoxic therapy. HIV+ does NOT contraindicate standard regimens but requires: - cART continuation throughout cytotoxic therapy (avoid AZT — myelotoxic; integrase-inhibitor backbone preferred) - PJP + MAC prophylaxis if CD4 < 200 - CNS prophylaxis (intrathecal MTX) for HIV-associated DLBCL / Burkitt regardless of CNS-IPI score - Screen for KSHV / HHV-8 if effusion lymphoma suspected Wired into CHL, DLBCL, Burkitt, MM, SMZL 1L algorithm etiology rails (notes only at present — full branching on HIV+ deferred to next round). reviewer_signoffs: 0 # STUB — pending two Clinical Co-Lead approvals

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