Rearranjo do BCL6 (3q27) pelo separador FISH

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ID	`BIO-BCL6-REARRANGEMENT`
Tipo	Biomarcador
Alegais	Rearranjo da BCL6Rearranjo BCL6 (3q27) — separador FISH
Estado	reviewed 2026-04-25 \| pending_clinical_signoff
Doenças	`DIS-HGBL-DH`
Fontes	`SRC-NCCN-BCELL-2025`

Fatos de biomarcadores

Tipo de biomarcador	gene_fusion
Detalhes da mutação	{"functional_impact": "constitutive BCL6 over-expression — blocks differentiation, drives germinal-center program", "gene": "BCL6", "variant_type": "fusion (multiple partners; promoter substitution → over-expression)"}
Medição	MétodoSonda de separação FISH em biópsia de FFPE Unidadescategorical (positive \| negative)
Biomarcadores relacionados	`BIO-DOUBLE-HIT` `BIO-MYC-REARRANGEMENT` `BIO-BCL2-REARRANGEMENT`

Notas

Cross-disease relevance: - **HGBL-DH/THL**: BCL6 rearrangement is the third member of double-/ triple-hit definition. MYC + BCL6 = double-hit (less common than MYC + BCL2). MYC + BCL2 + BCL6 = triple-hit (rarest, worst prognosis). Drives DA-EPOCH-R over R-CHOP. - **DLBCL**: ~20-30% have isolated BCL6 rearrangement — does NOT drive treatment alone (only when combined with MYC). - **FL**: rare ~10%. Required FISH on every newly-diagnosed DLBCL alongside MYC + BCL2 to identify HGBL-DH/THL early.

Usado por

Biomarcador

BIO-BCL6-IHC - BCL6 IHC (expressão de proteínas)
BIO-DOUBLE-HIT - Duplo golpe (MYC + BCL2 e/ou rearranjos BCL6)

Indicação

IND-HGBL-DH-1L-DAEPOCHR - IND-HGBL-DH-1L-DAEPOCHR
IND-HGBL-DH-1L-RCHOP - IND-HGBL-DH-1L-RCHOP

Questionários

QUEST-HGBL-DH-1L-STUB - Linfoma B-Cell de alta qualidade, Duplo-Hit / Triplo-Hit — primeira linha