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BCL6 IHC (expressão de proteínas)

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IDBIO-BCL6-IHC
TipoBiomarcador
Alegais
Linfoma de células B 6 proteínaBCL-6 IHCBCL6 imuno-histoquímicaProteína BCL6
Estadoreviewed 2026-05-05 | pending_clinical_signoff
DoençasNenhuma declaração
FontesSRC-NCCN-BCELL-2025

Fatos de biomarcadores

Tipo de biomarcadorprotein_expression_ihc
Detalhes da mutação{"gene_id_ncbi": 604, "gene_symbol": "BCL6", "note": "BCL6 is a transcriptional repressor essential for germinal center (GC) B-cell development. BCL6 IHC detects nuclear protein expression (not rearrangement). Positive = nuclear staining. Threshold: >30% nuclear positivity typically used as cut-off for GC-origin classification (Hans algorithm). Note: BIO-BCL6-REARRANGEMENT is a distinct biomarker (chromosomal translocation detected by FISH) — different from BCL6 protein expression by IHC.\n"}
Medição
MétodoIHC em biópsia de FFPE. Anticorpo anti-BCL6 (clona PG-B6p). Teintura nuclear pontuada como % de células tumorais positivas. Limiar do algoritmo de Hans: >30% nucleos positivos = BCL6+. Pontuação automatizada em plataformas de patologia digital cada vez mais utilizada.
Biomarcadores relacionadosBIO-CD10-IHC BIO-MUM1-IHC BIO-DLBCL-COO-HANS BIO-BCL6-REARRANGEMENT BIO-MYC-REARRANGEMENT

Notas

BCL6 IHC is a core component of the Hans algorithm for DLBCL cell-of-origin classification. While gene expression profiling (GEP, Lymph2Cx assay) is the reference standard for GCB/ABC classification, Hans IHC is widely used in resource-limited settings (concordance with GEP ~80%). BCL6 protein expression is distinct from BCL6 chromosomal rearrangement (t(3;v) translocations detected by FISH) — both exist independently. BCL6 rearrangement occurs in ~25-35% of DLBCL and may be present in either GCB or non-GCB subtypes.

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Biomarcador