Onco Wiki / Red flag

Age ≥80 + ECOG ≥2 + comorbidity — ICI doublet toxicity prohibitive.

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

Red Flag Origin

Trigger Logic

{
  "all_of": [
    {
      "comparator": ">=",
      "finding": "age_years",
      "threshold": 80
    },
    {
      "any_of": [
        {
          "comparator": ">=",
          "finding": "ecog_status",
          "threshold": 2
        },
        {
          "comparator": ">=",
          "finding": "comorbidity_count",
          "threshold": 2
        }
      ]
    }
  ],
  "type": "composite_clinical"
}

Notes

Single-agent TKI or ICI mono (KEYNOTE-427) alternatives.

Used By

Red flag

• RF-RCC-IMDC-INTERMEDIATE-POOR-RISK - IMDC (International Metastatic RCC Database Consortium) intermediate or poor risk score i...