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PV or ET patient pregnant or planning pregnancy — HU and anagrelide contraindicated; swit...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

IDRF-PV-ET-PREGNANCY-OR-PLANNING
TypeRed flag
Statusreviewed 2026-04-25 | pending_clinical_signoff
DiseasesDIS-ET DIS-PV
SourcesSRC-ESMO-MPN-2015 SRC-NCCN-MPN-2025

Red Flag Origin

DefinitionPV or ET patient pregnant or planning pregnancy — HU and anagrelide contraindicated; switch to interferon-α (PEG-IFN-α2a or ropeginterferon)
Clinical directioninvestigate
Categoryfrailty-age

Trigger Logic

{
  "any_of": [
    {
      "finding": "pregnancy_status",
      "value": "pregnant"
    },
    {
      "finding": "pregnancy_planning",
      "value": true
    },
    {
      "finding": "fertility_preservation_priority",
      "value": true
    }
  ],
  "type": "composite"
}

Notes

Direction "investigate" — surfaces an agent-substitution annotation. Pregnancy in MPN is high-risk (placental thrombosis, IUGR, miscarriage) and requires hematology + maternal-fetal-medicine co-management. Interferon-α is the cytoreductive agent of choice during pregnancy (no teratogenicity signal). LMWH (postpartum especially) is added for thrombosis prevention. STUB — requires clinical co-lead signoff.

Used By

Algorithms

Indications