Mid-treatment PET-CT progression (Deauville 4-5 with new lesions or SUVmax increase >25%)...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-PMBCL-TRANSFORMATION-PROGRESSION`
Type	Red flag
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-PMBCL`
Sources	`SRC-ESMO-DLBCL-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	Mid-treatment PET-CT progression (Deauville 4-5 with new lesions or SUVmax increase >25%) — switch to salvage 2L pathway, do not continue same regimen.
Clinical direction	investigate
Category	transformation-progression

Trigger Logic

{
  "any_of": [
    {
      "comparator": ">=",
      "finding": "pet_deauville_score",
      "threshold": 4
    },
    {
      "finding": "interim_pet_progression",
      "value": true
    }
  ],
  "type": "imaging_finding"
}

Notes

Mid-therapy progression triggers a 2L salvage handoff (separate Algorithm). 1L decision_tree is unaffected; flag surfaces as MDT-brief priority annotation.

Used By

Algorithms

ALGO-PMBCL-2L - ALGO-PMBCL-2L