Cardiac dysfunction (LVEF <50%) at baseline — both PMBCL 1L arms contain doxorubicin; car...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-PMBCL-ORGAN-DYSFUNCTION`
Type	Red flag
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-PMBCL`
Sources	`SRC-ESMO-DLBCL-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	Cardiac dysfunction (LVEF <50%) at baseline — both PMBCL 1L arms contain doxorubicin; cardio-oncology evaluation and ECG/echo monitoring required.
Clinical direction	investigate
Category	organ-dysfunction

Trigger Logic

{
  "any_of": [
    {
      "comparator": "<",
      "finding": "lvef_percent",
      "threshold": 50
    },
    {
      "finding": "cardiac_dysfunction_baseline",
      "value": true
    }
  ],
  "type": "lab_value"
}

Notes

Both 1L arms (DA-EPOCH-R, R-CHOP+RT) anthracycline-based; no anthracycline-free standard. Surfaces as cardio-onc consult + dose-modification supportive care.

Used By

Algorithms

ALGO-PMBCL-1L - ALGO-PMBCL-1L
ALGO-PMBCL-2L - ALGO-PMBCL-2L