OpenOnco
UA EN
Plan Builder Onco Wiki Tumor Board

Onco Wiki / Red flag

Age ≥75 + ECOG ≥2 + significant comorbidity — concurrent CRT and platinum-doublet chemo p...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

IDRF-NSCLC-FRAILTY-AGE
TypeRed flag
Statuspending_clinical_signoff
DiseasesDIS-NSCLC
SourcesSRC-ESMO-NSCLC-EARLY-2024 SRC-NCCN-NSCLC-2025

Red Flag Origin

DefinitionAge ≥75 + ECOG ≥2 + significant comorbidity — concurrent CRT and platinum-doublet chemo poorly tolerated; consider sequential CRT, weekly chemo + ICI, or single-agent / best-supportive-care for fragile patients.
Clinical directionde-escalate
Categoryfrailty-age

Trigger Logic

{
  "all_of": [
    {
      "comparator": ">=",
      "finding": "age_years",
      "threshold": 75
    },
    {
      "any_of": [
        {
          "comparator": ">=",
          "finding": "ecog_status",
          "threshold": 2
        },
        {
          "comparator": ">=",
          "finding": "comorbidity_count",
          "threshold": 2
        }
      ]
    }
  ],
  "type": "composite_clinical"
}

Notes

Geriatric assessment (G8 / CGA) recommended pre-treatment for ≥70. PD-L1≥50% driver-negative elderly: pembrolizumab mono is the best-tolerated option preserving OS benefit.

Used By

Algorithms

Indications