Non-small cell lung cancer · line 1 · Amivantamab + Lazertinib (MARIPOSA) — 1L EGFR-mut NSCLC
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
Knowledge-base record for audit. Provisional clinical content: this is not a prescription. An oncologist must verify original sources, applicability and review status. Full rules and constraints are in the YAML.
| Line of therapy | 1 |
|---|---|
| Track | aggressive |
| Linked regimen | REG-AMI-LAZ-NSCLC |
| ID | IND-NSCLC-EGFR-1L-AMI-LAZ |
|---|---|
| Type | Indication |
| Status | reviewed 2026-05-09 | pending_clinical_signoff | actionability review required |
| Diseases | DIS-NSCLC |
| Sources | SRC-ESMO-NSCLC-METASTATIC-2024 SRC-MARIPOSA-CHO-2024 SRC-NCCN-NSCLC-2025 |
Notes
STUB — pending Clinical Co-Lead sign-off (CHARTER §6.1: ≥2 reviewer signoffs to publish). Aggressive-track 1L for EGFR-mut metastatic NSCLC per MARIPOSA (Cho NEJM 2024). PFS HR 0.70 vs osimertinib mono; FDA approved Aug 2024 as 1L alternative. Distinct entity from IND-NSCLC-EGFR-MUT-MET-1L (osi mono standard-track 1L), IND-NSCLC-2L-EGFR-POST-OSI-AMI-LAZ (2L post-osi via MARIPOSA-2), and IND-NSCLC-2L-EGFR-EX20INS-AMIVANTAMAB (2L ex20ins). Reuses DRUG-AMIVANTAMAB and DRUG-LAZERTINIB; new REG-AMI-LAZ-NSCLC because MARIPOSA dosing differs from MARIPOSA-2 protocol (no split day 1+2; no chemo-combo arms).
Used By
No reverse references found in the YAML corpus.