Rapid AFP rise (>50% increase in 4-8 weeks) during systemic HCC therapy suggests progress...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-HCC-AFP-RAPID-RISE`
Type	Red flag
Status	reviewed 2026-04-26 \| pending_clinical_signoff
Diseases	`DIS-HCC`
Sources	`SRC-AASLD-HCC-2023` `SRC-NCCN-HCC-2025`

Red Flag Origin

Definition	Rapid AFP rise (>50% increase in 4-8 weeks) during systemic HCC therapy suggests progression. Triggers urgent re-imaging + MDT review for treatment change before clinical decline.
Clinical direction	investigate
Category	transformation-progression

Trigger Logic

{
  "any_of": [
    {
      "finding": "afp_rise_50pct_in_4_8wk",
      "value": true
    },
    {
      "all_of": [
        {
          "comparator": ">=",
          "finding": "afp_baseline_ng_ml",
          "threshold": 100
        },
        {
          "comparator": "<=",
          "finding": "afp_doubling_time_weeks",
          "threshold": 8
        }
      ]
    }
  ],
  "type": "composite_score"
}

Notes

AFP velocity is a recognized response/progression signal in AFP-secretors (pre-treatment AFP ≥100). Not all HCCs secrete AFP — ~30% remain AFP-non-secretors. Always re-image (CECT or MRI) before declaring progression — pseudoprogression on ICI mimics rise.

Used By

No reverse references found in the YAML corpus.