Infection-screening gate before esophageal cancer systemic therapy: HBsAg+ / anti-HBc+ (H...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-ESOPH-INFECTION-SCREENING`
Type	Red flag
Status	reviewed 2026-04-26 \| pending_clinical_signoff
Diseases	`DIS-ESOPHAGEAL`
Sources	`SRC-ESMO-ESOPHAGEAL-2024` `SRC-NCCN-ESOPHAGEAL-2025`

Red Flag Origin

Definition	Infection-screening gate before esophageal cancer systemic therapy: HBsAg+ / anti-HBc+ (HBV reactivation on pembro/nivo + chemo + dex), HIV+, OR active TB. Critical pre-CROSS / FLOT / definitive CRT and pre-adjuvant nivolumab.
Clinical direction	hold
Category	infection-screening

Trigger Logic

{
  "any_of": [
    {
      "finding": "hbsag",
      "value": "positive"
    },
    {
      "finding": "anti_hbc_total",
      "value": "positive"
    },
    {
      "finding": "hiv_status",
      "value": "positive"
    },
    {
      "finding": "active_tb",
      "value": true
    }
  ],
  "type": "lab_value"
}

Notes

Standard pattern; entecavir/TDF prophylaxis from -7d through 12 mo post-anti-PD-1.

Used By

No reverse references found in the YAML corpus.