Onco Wiki / Indication

Pheochromocytoma and paraganglioma (PPGL) · line 1 · Preoperative alpha-adrenergic blockade (phenoxybenzamine, before pheochromocytoma/paraganglioma surgery)

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

Knowledge-base record for audit. Provisional clinical content: this is not a prescription. An oncologist must verify original sources, applicability and review status. Full rules and constraints are in the YAML.

Source YAML: complete record

Line of therapy1
Tracklocal_therapy
Linked regimenREG-ALPHA-BLOCKADE-PREOP-PHEO
IDIND-PHEO-LOCALIZED-1L-ALPHA-BLOCKADE-ADRENALECTOMY
TypeIndication
Statusreviewed 2026-07-11
DiseasesDIS-PHEOCHROMOCYTOMA
SourcesSRC-ENDOCRINE-SOCIETY-PPGL-2014 SRC-NCCN-NET-2025

Notes

Coverage-enabling local-therapy indication for DIS-PHEOCHROMOCYTOMA. Models surgery NARRATIVELY (via stage_requirements/rationale/do_not_do) rather than via the phases:/surgery_id mechanism used by the meningioma gold-standard example, because no Surgery/Procedure entity for laparoscopic or cortical-sparing adrenalectomy exists in the KB yet and creating one was outside the entity set this pass was scoped to (Algorithm/Indication/Regimen/Drug/RedFlag/Source only) -- flagged as a follow-up PR on the Disease file. recommended_regimen therefore points at the mandatory alpha-blockade regimen (REG-ALPHA-BLOCKADE-PREOP-PHEO), the actual drug-level component of this pathway, with the hard RF-PHEO-INADEQUATE-ALPHA-BLOCKADE gate carrying the sequencing rule. Requires endocrine surgery / anesthesiology co-lead signoff before clinical publication.

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