t(11;14)(q13;q32) IGH/CCND1 by FISH

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`BIO-T11-14-IGH-CCND1`
Type	Biomarker
Aliases	t(11;14) IGH/CCND1 translocationt(11;14)(q13;q32) IGH/CCND1 (FISH)
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	None declared
Sources	`SRC-NCCN-BCELL-2025` `SRC-NCCN-MM-2025`

Biomarker Facts

Biomarker type	gene_fusion
Mutation details	{"functional_impact": "constitutive cyclin D1 over-expression → cell-cycle dysregulation", "gene": "CCND1", "variant_type": "fusion (t(11;14)(q13;q32) IGH/CCND1)"}
Measurement	MethodFISH break-apart or dual-fusion probe on FFPE biopsy or BM Unitscategorical (positive \| negative)
Related biomarkers	`BIO-CCND1-IHC`

Notes

Cross-disease use: - **MCL** (defining ~95%) — diagnostic - **MM** (~15-20%) — favorable cytogenetic + venetoclax-sensitive subset - Some HCL + plasmablastic lymphomas Diagnostic-defining for MCL; algorithm-impacting for MM r/r as venetoclax-responsive flag.

Used By

Actionability

BMA-CCND1-T1114-MCL - t(11;14) IGH/CCND1 is the defining genetic lesion of MCL — drives cyclin D1 overexpressio...
BMA-CCND1-T1114-MM - t(11;14) myeloma (~15-20%) — distinct biology with high BCL2/MCL1 ratio. Venetoclax monot...

Biomarker

BIO-CCND1-IHC - Cyclin D1 expression by IHC (encoded by CCND1)

Indications

IND-MCL-1L-BTKI-R - IND-MCL-1L-BTKI-R
IND-MCL-1L-INTENSIVE - IND-MCL-1L-INTENSIVE

Questionnaires

QUEST-MCL-1L-STUB - Mantle Cell Lymphoma — first line