ROS1 fusion
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
| ID | BIO-ROS1-FUSION |
|---|---|
| Type | Biomarker |
| Aliases | Фузія ROS1 |
| Status | pending_clinical_signoff |
| Diseases | None declared |
| Sources | None declared |
Biomarker Facts
| Biomarker type | gene_fusion |
|---|---|
| Mutation details | {"functional_impact": "Constitutive ROS1 kinase activation", "gene": "ROS1", "partners": ["CD74 (most common)", "EZR", "SLC34A2", "SDC4", "and others"], "type": "chromosomal rearrangement"} |
| Measurement | MethodRNA-based NGS OR FISH OR IHC screen Sensitivity requirementSame as ALK |
| Related biomarkers | None declared |
Notes
Often co-tested with ALK on same NGS panel.
Used By
Actionability
BMA-ROS1-CD74-NSCLC- CD74-ROS1 is the most common ROS1 fusion partner in NSCLC (~40-50% of ROS1+ cases) and as...BMA-ROS1-EZR-NSCLC- EZR-ROS1 (~15% of ROS1+ NSCLC) treated identically to other ROS1 fusions. Standard 1L: en...BMA-ROS1-FUSION-NSCLC- ROS1 rearrangement in advanced NSCLC: entrectinib (CNS-active) and crizotinib have establ...BMA-ROS1-G2032R-NSCLC- ROS1 G2032R is the dominant solvent-front resistance mutation after crizotinib or entrect...BMA-ROS1-SLC34A2-NSCLC- SLC34A2-ROS1 fusion (~10% of ROS1+ NSCLC) responds to standard ROS1-TKI therapy identical...
Biomarker
BIO-ROS1-G2032R- ROS1 G2032R resistance mutation
Diseases
DIS-IMT- Inflammatory myofibroblastic tumor (IMT)
Indications
IND-NSCLC-2L-PD-L1-POST-IO-DOCETAXEL- IND-NSCLC-2L-PD-L1-POST-IO-DOCETAXELIND-NSCLC-2L-ROS1-POST-CRIZ-ENTRECTINIB- IND-NSCLC-2L-ROS1-POST-CRIZ-ENTRECTINIBIND-NSCLC-2L-ROS1-REPOTRECTINIB- IND-NSCLC-2L-ROS1-REPOTRECTINIBIND-NSCLC-ROS1-1L-REPOTRECTINIB- IND-NSCLC-ROS1-1L-REPOTRECTINIB
Questionnaires
QUEST-NSCLC-1L-STUB- Non-small cell lung cancer — first line
Red flag
RF-IMT-HIGH-RISK-BIOLOGY- Inflammatory myofibroblastic tumor with actionable fusion driver: ALK fusion (TPM3-ALK, T...RF-NSCLC-HIGH-RISK-BIOLOGY- Actionable molecular driver detected (EGFR / ALK / ROS1 / KRAS G12C / BRAF V600E / MET ex...
Tests
TEST-NSCLC-NGS-PANEL- NSCLC comprehensive NGS panel (DNA + RNA fusion)