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Primary Mediastinal (Thymic) Large B-Cell Lymphoma · line 1 · Dose-adjusted EPOCH + rituximab (DA-EPOCH-R)

Vue déterministe de l'entité source de la LJAM. L'autorité clinique demeure avec les ID de la source cités et l'état d'approbation de l ́examinateur.

Contenu clinique provisoire : il ne s'agit pas d'une ordonnance. Un oncologue doit vérifier les sources originales, l'applicabilité et le statut de révision.

Source YAML: dossier complet

Ligne thérapeutique1
Voiestandard
Régime liéREG-DA-EPOCH-R
IDIND-PMBCL-1L-DA-EPOCH-R
TypeIndication
Étatpending_clinical_signoff
MaladiesDIS-PMBCL
SourcesSRC-ESMO-LYMPHOMA-2025 SRC-NCCN-BCELL-2025

Notes

STUB — pending Clinical Co-Lead approval. End-of-induction PET-CT визначає чи потрібна consolidation RT (Deauville 4-5 → RT; 1-3 → no RT).

Evidence for specific statements

These citations cover only the statements and scopes shown. They do not establish clinical approval of this record.

The prospective single-group NCI cohort included 51 untreated PMBCL patients. Its reported 93% endpoint is event-free survival during a median five years of follow-up; it must not be labelled progression-free survival or an individual probability of cure.

Endpoint terminology in the cited NCI cohort only; not verification of other response/survival estimates, RT rules, treatment selection or the entire indication.

SRC-DUNLEAVY-PMBCL-DAEPOCH-2013

Dunleavy 2013 primary abstract: Methods and Results.

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