Onco Wiki / Drogue

Pasireotide

Vue déterministe de l'entité source de la LJAM. L'autorité clinique demeure avec les ID de la source cités et l'état d'approbation de l ́examinateur.

IDDRUG-PASIREOTIDE
TypeMédicament
Alias
SignifSignifor LARПасиреотид
Étatreviewed 2026-07-11 | pending_clinical_signoff
MaladiesDIS-PITUITARY-ADENOMA
SourcesSRC-NCCN-CNS-2025

Faits sur les drogues

CatégorieAnalogique de la somatostatine (récepteur multi-STR1/2/3/5, affinité élevée SSTR5)
MécanismeCyclohexapeptide somatostatin analogue binding SSTR1, SSTR2, SSTR3, and particularly SSTR5 — the receptor subtype most highly expressed on corticotroph adenomas — distinguishing pasireotide from the largely SSTR2-selective first-generation SSAs (octreotide, lanreotide). Suppresses ACTH secretion from corticotroph adenomas (Cushing disease) and, via SSTR2/SSTR5, GH/IGF-1 secretion from somatotroph adenomas (acromegaly), including tumors with an inadequate response to first-generation SSA. Two formulations: subcutaneous (short-acting, Cushing disease) and long-acting release (LAR, intramuscular monthly — acromegaly and surgery-ineligible/persistent Cushing disease).
Dose typiqueCushing disease: pasireotide SC starting dose 0.6 mg subcutaneously twice daily, titrated per cortisol response and tolerability (product-label range approximately 0.3-0.9 mg SC BID); long-acting pasireotide LAR 10 mg IM every 4 weeks is an alternative for Cushing disease not amenable to surgery, titrated per response. Acromegaly: pasireotide LAR starting dose 40 mg IM every 4 weeks, titrated up to 60 mg IM q4w per IGF-1 response, typically reserved for inadequate response to first-generation SSA (octreotide/lanreotide). Confirm exact titration schedule with treating endocrinology team.
Ukraine enregistréeFaux
NSZU rembourséFaux
Ukraine vérifiée pour la dernière fois2026-07-11

Notes

STUB pending clinical co-lead signoff (CHARTER §6.1 — dev-mode-exempted, safe to merge as draft content, not published/verified clinical advice). Pasireotide is the medical option named in the Disease narrative for Cushing disease and is also listed among acromegaly SSA options. Modeled here as a single Drug entity covering both SC (Cushing) and LAR (acromegaly + surgery-ineligible Cushing) formulations, consistent with how this KB models other multi-formulation drugs. Steroidogenesis inhibitors named alongside pasireotide in the Cushing narrative (ketoconazole, metyrapone, osilodrostat) are not separately authored as Drug entities in this pass — see DIS-PITUITARY-ADENOMA proposal notes.

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Indication

Protocole thérapeutique