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ARN du VHC quantitative — surveillance de la charge virale pendant le traitement antiviral à action directe (DAA)

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IDBIO-HCV-RNA-QUANTITATIVE-MONITORING
TypeBiomarqueur
Alias
PCR du VHC quantitativeSurveillance quantitative de l'ARN du VHCSurveillance de la charge virale du VHCHCV РНК кількісна — моніторинг вірусного навантаження під час DAA-терапіїÉvaluation de la RVS12
Étatreviewed 2026-05-18 | pending_clinical_signoff
MaladiesDIS-HCV-MZL
SourcesSRC-AASLD-IDSA-HCV-2023 SRC-EASL-HCV-2023

Données biomarqueurs

Type de biomarqueurviral_load
Mesure
MéthodeReal-time quantitative PCR (HCV RNA, IU/mL); high-sensitivity assay (LOD ≤15 IU/mL) required for SVR12
UnitésIU/mL
Échelle type
  • 0
  • 100000000
Biomarqueurs connexesBIO-HCV-RNA BIO-HCV-STATUS

Notes

Quantitative HCV RNA used to TRACK response over time during 8-12 week course of direct-acting antiviral (DAA) regimens (glecaprevir/ pibrentasvir, sofosbuvir/velpatasvir, sofosbuvir/velpatasvir/voxilaprevir, ledipasvir/sofosbuvir). Distinct from BIO-HCV-RNA which captures the single-timepoint quantitative result; this entry captures the serial-monitoring concept for HCC prevention pathway. AASLD-IDSA / EASL minimum testing protocol: baseline HCV RNA + genotype + cirrhosis staging; on-treatment HCV RNA at week 4 (optional, evaluates adherence/response — undetectable at week 4 = rapid virologic response, RVR; not a stopping rule for modern DAAs); end-of-treatment HCV RNA at completion (week 8 or 12); SVR12 — undetectable HCV RNA 12 weeks after treatment completion = virologic cure (>95% achievable with current DAAs, durable in >99%). SVR12 = primary efficacy endpoint for HCV cure; SVR24 essentially equivalent. Post-SVR HCC surveillance remains REQUIRED in cirrhotic patients (cumulative HCC risk reduced but not eliminated by cure; AASLD recommends ongoing q6-month US ± AFP for cirrhotics regardless of SVR status). Quantitative monitoring also informs reinfection detection (any HCV R...

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Pertinence thérapeutique