Onco Wiki / Bandera roja

Infección persistente de alto riesgo por VPH (HPV-16, 18, 31, 33, 45, 52, 58 detectada en el...

Vista determinista de la entidad fuente YAML. La autoridad clínica sigue con los ID de fuente citados y estado de firma del revisor.

IDRF-CHRONIC-HPV-MALIGNANCY-PREVENTION
TipoSeñal de alerta
Situaciónreviewed 2026-05-18 | pending_clinical_signoff
EnfermedadesDIS-ANAL-SCC DIS-CERVICAL
FuentesSRC-NCCN-ANAL-2025 SRC-NCCN-CERVICAL-2025

Origen de la bandera roja

DefiniciónPersistent high-risk HPV infection (HPV-16, 18, 31, 33, 45, 52, 58 detected on cervical co-test, anal cytology, or oropharyngeal swab), or absence of completed HPV vaccination series in age-eligible individual. IARC Group 1 carcinogen (HPV) — established etiological driver of cervical (>99% attributable), anal (~90%), oropharyngeal (~70% in US/EU), vulvar/vaginal, and penile squamous cell carcinomas. HPV vaccination (Gardasil-9 nonavalent) reduces incidence; screening (cervical Pap/HPV co-testing, anal cytology in high-risk groups) enables early-stage detection. Prevention-persona RedFlag (§20 ratification 2026-05-18).
Dirección clínicainvestigación
Categoríaotros

Lógica de activación

{
  "any_of": [
    {
      "finding": "hpv_high_risk_status",
      "value": "positive"
    },
    {
      "finding": "hpv_vaccine_status",
      "value": "incomplete"
    },
    {
      "finding": "hpv_vaccine_status",
      "value": "unvaccinated"
    }
  ],
  "type": "lab_value"
}

Notas

Prevention-persona RedFlag for HPV-associated cancer prevention. Fires on persistent high-risk HPV positivity OR incomplete/absent vaccination in age-eligible individual. Engine routes to PreventionPlan recommending vaccination (Gardasil-9) and/or risk-group-appropriate screening cadence (cervical: USPSTF Pap+HPV co-test q5y ages 30-65; anal: HRA + cytology q1y in MSM/HIV+/post-transplant). STUB pending Co-Lead review. Cancer scope: anchored to DIS-CERVICAL and DIS-ANAL-SCC. Oropharyngeal squamous cell carcinoma and vulvar/vaginal/penile not yet in KB — v0.2-A authoring backlog.

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