Cromogranina A (GEP-NET vigilancia, MEN1)
Vista determinista de la entidad fuente YAML. La autoridad clínica sigue con los ID de fuente citados y estado de firma del revisor.
| ID | BIO-CHROMOGRANIN-A-NET |
|---|---|
| Tipo | Biomarcador |
| Aliaces | CHGACgACromogranina AХромогранін A (нагляд GEP-NET, MEN1) |
| Situación | reviewed 2026-05-18 | pending_clinical_signoff |
| Enfermedades | DIS-PNET |
| Fuentes | SRC-ENDOCRINE-SOCIETY-MEN-2023 SRC-NCCN-NET-2025 |
Datos sobre biomarcadores
| Tipo de biomarcador | serum_marker |
|---|---|
| Medición | MétodoInmunoensayo sérico (RIA o ELISA); rangos de referencia dependientes del ensayo Unidadesng/mL Alcance típico
|
| Productos químicos y químicos | Ninguna declarada |
Notas
Granin-family secretory protein, ubiquitously expressed in neuroendocrine cells. Used as a non-specific biomarker for GEP-NET (gastroenteropancreatic neuroendocrine tumors), MEN1-associated NETs (pancreatic, foregut), and pheochromocytoma (but plasma metanephrines preferred for pheo). NCCN recommends CgA as ADJUNCT, not standalone — annual surveillance in MEN1 carriers (pancreatic NET screening) typically combined with cross-sectional imaging (MRI or EUS) and gastrin/insulin/glucagon/VIP/PP panels per symptoms. Major confounders driving false-positive elevations: proton-pump inhibitor use (most common cause of elevation in clinical practice), atrophic gastritis, renal impairment, heart failure, chronic hepatitis, IBD. Less sensitive than gut-hormone panel for functional NETs. Limited utility for non-functioning small NETs. STUB pending two-Co-Lead signoff.
Utilizado por
Relevancia terapéutica
BMA-CHROMOGRANIN-A-NET-MEN1-SURVEILLANCE- La cromogranina A (CgA) es una proteína secretaria de la familia de la granina, expresada en...