PD-L1 CPS es una puntuación continua de IHC utilizada como umbral de elegibilidad para ICI que contiene r...
Vista determinista de la entidad fuente YAML. La autoridad clínica sigue con los ID de fuente citados y estado de firma del revisor.
| ID | BMA-PDL1-CPS-GASTRIC |
|---|---|
| Tipo | Relevancia terapéutica |
| Situación | reviewed 2026-05-07 | actionability review required |
| Enfermedades | DIS-GASTRIC |
| Fuentes | SRC-CHECKMATE-649-JANJIGIAN-2022 SRC-ESMO-GASTRIC-2024 SRC-NCCN-GASTRIC-2025 |
Hechos relativos a la posibilidad de adoptar medidas
| Biomarcador | BIO-PDL1-CPS |
|---|---|
| Enfermedad | DIS-GASTRIC |
| El nivel de ESCAT | IA |
| Combinaciones recomendadas | nivolumab + fluoropyrimidine + platinum (CPS≥5, 1L per SRC-NCCN-GASTRIC-2025, SRC-ESMO-GASTRIC-2024), nivolumab + FOLFOX/XELOX (CPS≥1 broader population per SRC-CHECKMATE-649-JANJIGIAN-2022) |
| Resumen de las pruebas | PD-L1 CPS is a continuous IHC score used as an eligibility threshold for ICI-containing regimens in metastatic gastric/GEJ adenocarcinoma. Thresholds vary by regimen: CPS ≥5 — nivolumab + fluoropyrimidine + platinum (CheckMate-649; mOS 14.4 vs 11.1 mo, HR 0.71 in CPS≥5 subgroup); CPS ≥1 — nivolumab + chemo as broader population (CM-649); CPS ≥1 — pembrolizumab + trastuzumab + chemo for HER2+ disease (KEYNOTE-811, covered separately in BMA-HER2-AMP-GASTRIC). Per NCCN and ESMO 2024, PD-L1 CPS testing by IHC 22C3 pharmDx is mandatory prior to 1L treatment selection. Threshold-gated indication selection is performed by the algorithm layer (IND-GASTRIC-METASTATIC-1L-PDL1-CHEMO-ICI); this BMA entry surfaces ESCAT tier context for tumor-board discussion only. |
Notas
Variant_qualifier is null (gene-level) — CPS is a continuous score; specific threshold gating (CPS≥5 vs ≥1) is enforced by the indication layer, not this BMA cell. This entry exists to prevent the render layer from showing "Not in KB" for a well-defined, FDA-approved biomarker. KEYNOTE-811 evidence is attributable to BMA-HER2-AMP-GASTRIC to avoid overlap.
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