HGBL double-/triple-hit lymphoma — biology alone meets CNS-prophylaxis indication indepen...

Deterministische Ansicht der Quelle YAML Entität. Klinische Autorität bleibt mit den zitierten Quell-IDs und Rezensenten Sign-off Zustand.

ID	`RF-HGBL-DH-CNS-PROPHYLAXIS-TRIGGER`
Art	Warnhinweis
Status	reviewed 2026-04-27 \| pending_clinical_signoff
Erkrankungen	`DIS-HGBL-DH`
Quellen	`SRC-ESMO-DLBCL-2024` `SRC-NCCN-BCELL-2025`

Ursprung der Roten Flagge

Begriffsbestimmung	HGBL double-/triple-hit lymphoma — biology alone meets CNS-prophylaxis indication independent of CNS-IPI; mandates HD-MTX intercalation or IT MTX
Klinische Richtung	Untersuchung
Kategorie	high-risk-biology

Logik auslösen

{
  "any_of": [
    {
      "finding": "myc_rearranged",
      "value": true
    },
    {
      "finding": "double_hit_lymphoma",
      "value": true
    },
    {
      "finding": "triple_hit_lymphoma",
      "value": true
    }
  ],
  "type": "composite"
}

Anmerkungen

Per NCCN B-cell v.X.2025 HGBL section: CNS prophylaxis recommended for all HGBL-DH/TH regardless of CNS-IPI score (biology-driven); typical approach HD-MTX 3-3.5 g/m² IV intercalated with DA-EPOCH-R cycles. Direction INVESTIGATE because RF doesn't shift main regimen — adds CNS-directed therapy as plan particularity. shifts_algorithm:[] per REDFLAG_AUTHORING_GUIDE §4 rule 2. STUB — requires clinical co-lead signoff.

Verwendet von

Keine Rückverweise im YAML-Korpus gefunden.