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Low-grade glioma with raised intracranial pressure or refractory seizures requiring emerg...

Deterministische Ansicht der Quelle YAML Entität. Klinische Autorität bleibt mit den zitierten Quell-IDs und Rezensenten Sign-off Zustand.

IDRF-GLIOMA-LOW-GRADE-INTRACRANIAL-PRESSURE
ArtWarnhinweis
Statusreviewed 2026-04-27 | pending_clinical_signoff
ErkrankungenDIS-GLIOMA-LOW-GRADE
QuellenSRC-EANO-GBM-2024 SRC-NCCN-CNS-2025

Ursprung der Roten Flagge

BegriffsbestimmungLow-grade glioma with raised intracranial pressure or refractory seizures requiring emergency intervention: midline shift ≥5 mm, papilledema, GCS drop, status epilepticus or breakthrough seizures despite ≥2 AEDs
Klinische RichtungHalten
KategorieOrgandysfunktion
Schaltet AlgorithmusALGO-GLIOMA-LGG-1L

Logik auslösen

{
  "any_of": [
    {
      "finding": "raised_intracranial_pressure",
      "value": true
    },
    {
      "comparator": ">=",
      "finding": "midline_shift_mm",
      "threshold": 5
    },
    {
      "finding": "status_epilepticus",
      "value": true
    },
    {
      "finding": "refractory_seizures_on_2_aeds",
      "value": true
    },
    {
      "comparator": "<",
      "finding": "gcs_score",
      "threshold": 12
    }
  ],
  "type": "composite"
}

Anmerkungen

Per NCCN-CNS + EANO 2024: dexamethasone 4-16 mg/day for vasogenic edema; urgent neurosurgical evaluation for resection (max safe resection improves OS in LGG); levetiracetam preferred AED (no P450 induction → preserves chemo efficacy); status epilepticus treated per neurology emergency protocol. Direction HOLD on systemic / RT therapy until ICP managed and resection assessed. Priority 8. STUB — requires clinical co-lead signoff.

Verwendet von

Anwendungsgebiet