Chromogranin A (GEP-NET-Überwachung, MEN1)
Deterministische Ansicht der Quelle YAML Entität. Klinische Autorität bleibt mit den zitierten Quell-IDs und Rezensenten Sign-off Zustand.
| ID | BIO-CHROMOGRANIN-A-NET |
|---|---|
| Art | Biomarker |
| Aliase | CHGACgAChromogranin AХромогранін A (нагляд GEP-NET, MEN1) |
| Status | reviewed 2026-05-18 | pending_clinical_signoff |
| Erkrankungen | DIS-PNET |
| Quellen | SRC-ENDOCRINE-SOCIETY-MEN-2023 SRC-NCCN-NET-2025 |
Biomarker-Fakten
| Biomarker-Typ | serum_marker |
|---|---|
| Messung | VerfahrenSerumimmunassay (RIA oder ELISA); assapflichtige Bezugsbereiche Einheitenng/mL Typischer Bereich
|
| Verwandte Biomarker | None declared |
Anmerkungen
Granin-family secretory protein, ubiquitously expressed in neuroendocrine cells. Used as a non-specific biomarker for GEP-NET (gastroenteropancreatic neuroendocrine tumors), MEN1-associated NETs (pancreatic, foregut), and pheochromocytoma (but plasma metanephrines preferred for pheo). NCCN recommends CgA as ADJUNCT, not standalone — annual surveillance in MEN1 carriers (pancreatic NET screening) typically combined with cross-sectional imaging (MRI or EUS) and gastrin/insulin/glucagon/VIP/PP panels per symptoms. Major confounders driving false-positive elevations: proton-pump inhibitor use (most common cause of elevation in clinical practice), atrophic gastritis, renal impairment, heart failure, chronic hepatitis, IBD. Less sensitive than gut-hormone panel for functional NETs. Limited utility for non-functioning small NETs. STUB pending two-Co-Lead signoff.
Verwendet von
Therapeutische Relevanz
BMA-CHROMOGRANIN-A-NET-MEN1-SURVEILLANCE- Chromogranin A (CgA) ist ein granin-familiäres Sekretorprotein, das allgegenwärtig in Neuron...