Cyclophosphamide
Детермінований перегляд YAML-сутності з джерельної бази. Клінічний авторитет лишається за вказаними source ID та статусом клінічного sign-off.
| ID | DRUG-CYCLOPHOSPHAMIDE |
|---|---|
| Тип | Препарат |
| Синоніми | CytoxanEndoxanProcytoxЦиклофосфамід |
| Статус | переглянуто 2026-04-26 | очікує клінічного підпису |
| Хвороби | DIS-AITL DIS-ALCL DIS-ATLL DIS-B-ALL DIS-BREAST DIS-BURKITT DIS-DLBCL-NOS DIS-EATL DIS-FL DIS-HGBL-DH DIS-HSTCL DIS-MCL DIS-MELANOMA DIS-MM DIS-NLPBL DIS-PMBCL DIS-PTCL-NOS DIS-PTLD DIS-T-ALL DIS-WM |
| Джерела | SRC-NCCN-BCELL-2025 |
Дані про препарат
| Клас | alkylating_agent — nitrogen mustard (oxazaphosphorine) |
|---|---|
| Механізм дії | Prodrug activated by hepatic CYP2B6/CYP3A4 to phosphoramide mustard, which crosslinks DNA strands and induces apoptosis. Active in both proliferating and resting cells; broadly used in lymphoid neoplasms. |
| Типове дозування | 750 mg/m² IV day 1 of 21-day cycle (R-CHOP); 600-1500 mg/m² depending on regimen |
| Зареєстровано в Україні | True |
| Відшкодовується НСЗУ | True |
| Остання перевірка для України | 2026-04-27 |
Застереження
- Myelosuppression with infection risk
- Hemorrhagic cystitis (mitigated by mesna for high-dose)
- Cardiotoxicity at very high doses
- Secondary malignancies (long-term exposure)
Нотатки
Standard R-CHOP component. Premedication: 5-HT3 antagonist + dexamethasone. Mesna NOT routinely needed at R-CHOP doses (750 mg/m²) but mandatory for high-dose conditioning (>1500 mg/m²).
Де використовується
Regimens
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