Tumor de células granulosas adultas do ovário
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| ID | DIS-GRANULOSA-CELL |
|---|---|
| Tipo | Doença |
| Alegais | AGCTTumor de células granulosas adultasOvário do GCTTCG do tipo adultotumor de células granulosasДоросла гранульозоклітинна пухлина яєчника |
| Estado | reviewed 2026-05-04 | pending_clinical_signoff |
| Doenças | Nenhuma declaração |
| Fontes | SRC-ESMO-OVARIAN-2024 SRC-NCCN-OVARIAN-2025 |
Informational support. All recommendations must be verified by a qualified oncologist. Engineering checks are not clinical validation or treatment approval.
| icd_o_3_morphology | 8620/3 |
|---|---|
| icd_o_3_topography | ["C56"] |
| icd_10 | C56 |
| who_classification | WHO Classification of Female Genital Tumours 5th ed (2020): Adult granulosa cell tumour |
Notas
Adult GCT is defined molecularly by the FOXL2 p.C134W mutation (present in ~97% of cases), which is the only pathognomonic molecular alteration in any solid tumor. FOXL2 is a granulosa cell transcription factor; the C134W mutation is a dominant-negative gain-of-function that prevents normal granulosa cell differentiation. Clinically, tumors present with estrogen excess (abnormal uterine bleeding, endometrial pathology) or abdominal mass. Prognosis is generally favorable for stage I (90% 10-yr OS) but late recurrences (10–20 years) are characteristic. No FDA-approved targeted therapy as of 2026; FOXL2 inhibition and CDK4/6 inhibitors are in clinical trials. FOXL2 mutation testing is diagnostic, not therapeutic selection (ESCAT IIB — clinical utility as diagnostic/prognostic marker).
Usado por
Relevância terapêutica
BMA-FOXL2-GRANULOSA-CELL- FOXL2 p.C134W (c.402C>G) é o marcador molecular definidor do tumor de células granulosas adultas (...
Algoritmos
ALGO-GRANULOSA-CELL-1L- ALGO-GRANULOSA-CELL-1L
Doença
DIS-SERTOLI-LEYDIG-OVARIAN- Tumor de células Sertoli-Leydig do ovário
Indicação
IND-GRANULOSA-CELL-1L-CARBOPLATIN-PACLITAXEL- IND-GRANULOSA-CELL-1L-CARBOPLATIN-PACLITAXEL
Questionários
QUEST-GRANULOSA-CELL-1L-STUB- Tumor de células granulosas adultas — primeira linha