Cisplatin-ineligibility per Galsky criteria — drives EV+pembro 1L OR carbo-doublet.

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-UROTHELIAL-ORGAN-DYSFUNCTION`
Type	Red flag
Status	pending_clinical_signoff
Diseases	`DIS-UROTHELIAL`
Sources	`SRC-EAU-BLADDER-2024` `SRC-NCCN-BLADDER-2025`

Red Flag Origin

Definition	Cisplatin-ineligibility per Galsky criteria — drives EV+pembro 1L OR carbo-doublet.
Clinical direction	de-escalate
Category	organ-dysfunction

Trigger Logic

{
  "any_of": [
    {
      "comparator": "<",
      "finding": "creatinine_clearance_ml_min",
      "threshold": 60
    },
    {
      "finding": "hearing_loss_grade_2_or_higher",
      "value": true
    },
    {
      "finding": "peripheral_neuropathy_grade_2_or_higher",
      "value": true
    }
  ],
  "type": "composite_clinical"
}

Notes

EV+pembro (post-EV-302) eliminates cisplatin-eligibility as 1L bottleneck.

Used By

Indications

IND-UROTHELIAL-2L-ERDAFITINIB - IND-UROTHELIAL-2L-ERDAFITINIB