Severe cytopenia (ANC <0.5 OR platelets <50 OR Hgb <8) at diagnosis — disease-driven marr...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-T-PLL-ORGAN-DYSFUNCTION`
Type	Red flag
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-T-PLL`
Sources	`SRC-ESMO-PTCL-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	Severe cytopenia (ANC <0.5 OR platelets <50 OR Hgb <8) at diagnosis — disease-driven marrow infiltration; alemtuzumab will worsen lymphopenia; growth-factor support + transfusion threshold management critical.
Clinical direction	investigate
Category	organ-dysfunction

Trigger Logic

{
  "any_of": [
    {
      "comparator": "<",
      "finding": "anc_x10_9_l",
      "threshold": 0.5
    },
    {
      "comparator": "<",
      "finding": "platelets_x10_9_l",
      "threshold": 50
    },
    {
      "comparator": "<",
      "finding": "hemoglobin_g_dl",
      "threshold": 8
    }
  ],
  "type": "lab_value"
}

Notes

T-PLL cytopenias are disease-driven; alemtuzumab causes profound CD52+ lymphocyte depletion (months). Supportive care + opportunistic infection prophylaxis essential.

Used By

No reverse references found in the YAML corpus.