Complex karyotype (≥3 abnormalities), TP53 mutation/deletion, or Ki-67 >40% — aggressive...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-T-PLL-HIGH-RISK-BIOLOGY`
Type	Red flag
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-T-PLL`
Sources	`SRC-ESMO-PTCL-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	Complex karyotype (≥3 abnormalities), TP53 mutation/deletion, or Ki-67 >40% — aggressive variant; alemtuzumab response shorter; alloSCT consolidation prioritized.
Clinical direction	intensify
Category	high-risk-biology

Trigger Logic

{
  "any_of": [
    {
      "finding": "complex_karyotype",
      "value": true
    },
    {
      "finding": "tp53_mutation",
      "value": true
    },
    {
      "finding": "ki67_above_40_percent",
      "value": true
    }
  ],
  "type": "biomarker"
}

Notes

Complex karyotype/TP53 in T-PLL predicts alemtuzumab response duration <6 months; alloSCT urgently while in CR1.

Used By

No reverse references found in the YAML corpus.