Age >75 OR not alloSCT-eligible (ECOG ≥3, severe organ dysfunction) — alemtuzumab still a...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-T-PLL-FRAILTY-AGE`
Type	Red flag
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-T-PLL`
Sources	`SRC-ESMO-PTCL-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	Age >75 OR not alloSCT-eligible (ECOG ≥3, severe organ dysfunction) — alemtuzumab still appropriate but with palliative intent; reduced-intensity-conditioning alloSCT considered if borderline.
Clinical direction	investigate
Category	frailty-age

Trigger Logic

{
  "any_of": [
    {
      "comparator": ">",
      "finding": "age_years",
      "threshold": 75
    },
    {
      "comparator": ">=",
      "finding": "ecog_status",
      "threshold": 3
    }
  ],
  "type": "composite_clinical"
}

Notes

T-PLL incurable without alloSCT; alemtuzumab is bridge only. Frailty surfaces palliative-intent realism in MDT brief.

Used By

No reverse references found in the YAML corpus.