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Age >80 OR ECOG ≥3 with significant comorbidity AND asymptomatic SMZL — watch-and-wait ma...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

Red Flag Origin

Trigger Logic

{
  "all_of": [
    {
      "finding": "smzl_asymptomatic",
      "value": true
    },
    {
      "any_of": [
        {
          "comparator": ">",
          "finding": "age_years",
          "threshold": 80
        },
        {
          "all_of": [
            {
              "comparator": ">=",
              "finding": "ecog_status",
              "threshold": 3
            },
            {
              "comparator": ">=",
              "finding": "comorbidity_count",
              "threshold": 2
            }
          ]
        }
      ]
    }
  ],
  "type": "composite_clinical"
}

Notes

SMZL is indolent; in asymptomatic elderly, observation is GELF/iwCLL-style standard of care. Active treatment only for cytopenias / symptomatic splenomegaly / B-symptoms.

Used By

Algorithms

• ALGO-SMZL-2L - ALGO-SMZL-2L