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CNS metastases — ICI doublet retains intracranial activity; cabozantinib + nivolumab also...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

IDRF-RCC-TRANSFORMATION-PROGRESSION
TypeRed flag
Statuspending_clinical_signoff
DiseasesDIS-RCC
SourcesSRC-ESMO-RCC-2024 SRC-NCCN-KIDNEY-2025

Red Flag Origin

DefinitionCNS metastases — ICI doublet retains intracranial activity; cabozantinib + nivolumab also CNS-active.
Clinical directioninvestigate
Categorytransformation-progression

Trigger Logic

{
  "any_of": [
    {
      "finding": "cns_metastases_rcc",
      "value": true
    }
  ],
  "type": "composite_clinical"
}

Notes

RCC brain-met rate ~10%.

Used By

Indications