Sarcomatoid features OR rapid TKI progression — predicts ICI-doublet benefit; non-clear-c...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-RCC-HIGH-RISK-BIOLOGY`
Type	Red flag
Status	pending_clinical_signoff
Diseases	`DIS-RCC`
Sources	`SRC-ESMO-RCC-2024` `SRC-NCCN-KIDNEY-2025`

Red Flag Origin

Definition	Sarcomatoid features OR rapid TKI progression — predicts ICI-doublet benefit; non-clear-cell distinct path.
Clinical direction	intensify
Category	high-risk-biology

Trigger Logic

{
  "any_of": [
    {
      "finding": "rcc_sarcomatoid_features",
      "value": true
    },
    {
      "finding": "rcc_non_clear_cell",
      "value": true
    }
  ],
  "type": "composite_clinical"
}

Notes

Sarcomatoid clear-cell uniquely benefits from ICI doublet.

Used By

No reverse references found in the YAML corpus.