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Renal dysfunction (CrCl <50 mL/min) or severe hepatic impairment (Child-Pugh C) — limits...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

IDRF-PROSTATE-ORGAN-DYSFUNCTION
TypeRed flag
Statuspending_clinical_signoff
DiseasesDIS-PROSTATE
SourcesSRC-ESMO-PROSTATE-2024 SRC-NCCN-PROSTATE-2025

Red Flag Origin

DefinitionRenal dysfunction (CrCl <50 mL/min) or severe hepatic impairment (Child-Pugh C) — limits PARPi (olaparib renal-cleared) and ARPI (abiraterone hepatic) dosing.
Clinical directioninvestigate
Categoryorgan-dysfunction

Trigger Logic

{
  "any_of": [
    {
      "comparator": "<",
      "finding": "creatinine_clearance_ml_min",
      "threshold": 50
    },
    {
      "finding": "child_pugh_class",
      "value": "C"
    }
  ],
  "type": "composite_clinical"
}

Notes

Olaparib requires CrCl ≥31 (with dose-mod) for safe use; <30 avoid. Abiraterone Child-Pugh C: avoid. Surfaces in MDT as need for renal/ hepatic input.

Used By

Indications