Pre-treatment HBV/HCV/HIV serology + dental evaluation (denosumab/zoledronate ONJ risk; l...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-PROSTATE-INFECTION-SCREENING`
Type	Red flag
Status	pending_clinical_signoff
Diseases	`DIS-PROSTATE`
Sources	`SRC-ESMO-PROSTATE-2024` `SRC-NCCN-PROSTATE-2025`

Red Flag Origin

Definition	Pre-treatment HBV/HCV/HIV serology + dental evaluation (denosumab/zoledronate ONJ risk; lutetium-PSMA xerostomia) standard for mCRPC initiation.
Clinical direction	investigate
Category	infection-screening

Trigger Logic

{
  "any_of": [
    {
      "finding": "dental_clearance_pending",
      "value": true
    },
    {
      "finding": "hbsag",
      "value": "positive"
    }
  ],
  "type": "composite_clinical"
}

Notes

Cross-disease HBV reactivation handled by RF-UNIVERSAL-HBV-REACTIVATION- RISK. Dental clearance pre-bone-modifying-agent unique to bone-meta diseases (prostate, breast, MM).

Used By

Indications

IND-PROSTATE-MCRPC-2L-CABAZITAXEL - IND-PROSTATE-MCRPC-2L-CABAZITAXEL
IND-PROSTATE-MCRPC-2L-DOCETAXEL - IND-PROSTATE-MCRPC-2L-DOCETAXEL
IND-PROSTATE-MCRPC-2L-LU-PSMA - IND-PROSTATE-MCRPC-2L-LU-PSMA
IND-PROSTATE-MCRPC-2L-RADIUM223 - IND-PROSTATE-MCRPC-2L-RADIUM223