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Age ≥80 OR ECOG ≥3 with significant comorbidity — docetaxel poorly tolerated; ARPI monoth...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

Red Flag Origin

Trigger Logic

{
  "any_of": [
    {
      "comparator": ">=",
      "finding": "age_years",
      "threshold": 80
    },
    {
      "all_of": [
        {
          "comparator": ">=",
          "finding": "ecog_status",
          "threshold": 3
        },
        {
          "comparator": ">=",
          "finding": "comorbidity_count",
          "threshold": 2
        }
      ]
    }
  ],
  "type": "composite_clinical"
}

Notes

Triplet (ARASENS) carries significant docetaxel toxicity unsuitable for fragile elderly. ARPI monotherapy preserves OS benefit with tolerable AEs. Darolutamide preferred when cognitive AEs / falls are particularly concerning.

Used By

Algorithms

• ALGO-PROSTATE-MHSPC-1L - ALGO-PROSTATE-MHSPC-1L

Indications

• IND-PROSTATE-MHSPC-1L-TRIPLET - IND-PROSTATE-MHSPC-1L-TRIPLET