HIV serology mandatory at PCNSL diagnosis — HIV-associated PCNSL (CD4 <200) is treated di...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-PCNSL-INFECTION-SCREENING`
Type	Red flag
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-PCNSL`
Sources	`SRC-ESMO-DLBCL-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	HIV serology mandatory at PCNSL diagnosis — HIV-associated PCNSL (CD4 <200) is treated differently (cART optimization first, intrathecal ± lower-intensity systemic).
Clinical direction	investigate
Category	infection-screening

Trigger Logic

{
  "any_of": [
    {
      "finding": "hiv_serology",
      "value": "positive"
    },
    {
      "comparator": "<",
      "finding": "cd4_count_per_ul",
      "threshold": 200
    }
  ],
  "type": "biomarker"
}

Notes

HIV+ PCNSL (with CD4 <200) often EBV-driven; cART initiation alone can produce remissions. Distinct from immunocompetent PCNSL — flagged for MDT review and infectious-disease co-management; algorithm choice deferred.

Used By

No reverse references found in the YAML corpus.