Onco Wiki / Red flag

Age >70 OR ECOG ≥3 OR CrCl 50-70 mL/min — full-dose HD-MTX (≥3.5 g/m²) carries excessive...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

Red Flag Origin

Trigger Logic

{
  "any_of": [
    {
      "comparator": ">",
      "finding": "age_years",
      "threshold": 70
    },
    {
      "comparator": ">=",
      "finding": "ecog_status",
      "threshold": 3
    },
    {
      "all_of": [
        {
          "comparator": ">=",
          "finding": "creatinine_clearance_ml_min",
          "threshold": 50
        },
        {
          "comparator": "<=",
          "finding": "creatinine_clearance_ml_min",
          "threshold": 70
        }
      ]
    }
  ],
  "type": "composite_clinical"
}

Notes

Elderly PCNSL OS dominated by tolerability of induction; reduced-dose MTX with rituximab achieves comparable response rates with markedly less toxicity. Decision sits within Indication-level dose-adjustment, not 1L Algorithm branch.

Used By

Algorithms

• ALGO-PCNSL-1L - ALGO-PCNSL-1L
• ALGO-PCNSL-2L - ALGO-PCNSL-2L

Indications

• IND-PCNSL-2L-RMPV-SALVAGE - IND-PCNSL-2L-RMPV-SALVAGE