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High perioperative VTE risk in ovarian cancer: ascites + bulky pelvic mass + immobilizati...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

IDRF-OVARIAN-PERIOPERATIVE-VTE
TypeRed flag
Statusreviewed 2026-04-26 | pending_clinical_signoff
DiseasesDIS-OVARIAN
SourcesSRC-ESMO-OVARIAN-2024 SRC-NCCN-OVARIAN-2025

Red Flag Origin

DefinitionHigh perioperative VTE risk in ovarian cancer: ascites + bulky pelvic mass + immobilization + ovarian cancer's intrinsic prothrombotic state (~20% VTE incidence post-cytoreduction without prophylaxis). Mandates extended LMWH prophylaxis × 28 days post-op + careful timing of bevacizumab initiation (≥28 days post-op for surgical wound healing).
Clinical directioninvestigate
Categoryorgan-dysfunction

Trigger Logic

{
  "any_of": [
    {
      "finding": "active_vte_recent",
      "value": true
    },
    {
      "finding": "ascites_significant",
      "value": true
    },
    {
      "comparator": ">=",
      "finding": "bulky_pelvic_mass_cm",
      "threshold": 10
    }
  ],
  "type": "composite_score"
}

Notes

Khorana score >2 in ovarian = ambulatory VTE prophylaxis discussion. Bevacizumab adds bleeding risk; coordinate with surgical timing.

Used By

Algorithms

Indications