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Frailty profile precluding standard carbo+pacli + bev intensified induction in ovarian: E...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

IDRF-OVARIAN-FRAILTY-AGE
TypeRed flag
Statusreviewed 2026-04-26 | pending_clinical_signoff
DiseasesDIS-OVARIAN
SourcesSRC-ESMO-OVARIAN-2024 SRC-NCCN-OVARIAN-2025

Red Flag Origin

DefinitionFrailty profile precluding standard carbo+pacli + bev intensified induction in ovarian: ECOG ≥3, OR (age ≥75 + Charlson ≥3), OR composite (age ≥70 + ascites large-volume + albumin <3.0). Triggers carbo-mono OR weekly-dose-dense-pacli (less neuropathy / bone marrow).
Clinical directionde-escalate
Categoryfrailty-age
Shifts algorithmALGO-OVARIAN-ADVANCED-1L

Trigger Logic

{
  "any_of": [
    {
      "comparator": ">=",
      "finding": "ecog",
      "threshold": 3
    },
    {
      "all_of": [
        {
          "comparator": ">=",
          "finding": "age",
          "threshold": 75
        },
        {
          "comparator": ">=",
          "finding": "charlson_score",
          "threshold": 3
        }
      ]
    }
  ],
  "type": "composite_score"
}

Notes

EWOC-1 trial: 3-weekly carbo+pacli vs single-agent carbo for frail elderly — combination still won OS but reduced-dose acceptable. Bevacizumab caution in elderly (HTN + GI perforation risk).

Used By

Algorithms

Indications